Developed in 1994. By 2011, "Palmitoyl Oligopeptide" was the most used peptide in cosmetic products. In 2013, the name was "used to designate two distinct molecules" and those compounds were renamed as:
Palmitoyl Tripeptide-1 (Pal-GHK) and
Palmitoyl Hexapaptide-12 (Pal-KTTKS).
Both act by stimulating fibroblast activity, thus increasing matrix protein and glycosaminoglycan synthesis in the dermis. In other words, anti-aging peptides clinically proven to reduce wrinkle depth by stimulating the synthesis of collagen, elastin, glucosaminoglycans and hyaluronic acid in the deep layers of the skin.
In 2018, Palmitoyl Tripeptide-1 (Pal-GHK) was the second most used peptide in cosmetic formulations.
Matrixyl™ 3000 is the commercial name of a product that combines Palmitoyl Tripeptide-1 and Palmityol Tetrapeptide-7. Palmityol Tetrapeptide-7 was the second most used peptide in 2011.