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Bev Sidders Skincare Glossary

Biotinoyl Tripeptide-1

Biotin tripeptide-1 is an extracellular matrix (ECM) cell-communicating peptide (Palmitoyl Tripeptide-1) that has been conjugated to biotin.  It has been found helpful for reducing hair loss, increasing hair growth and making eye lashes appear longer, fuller and stronger.  

Biotinoyl tripeptide-1 increases the population of anagen hair, which is the active growth phase of hair follicles. It provokes the cells in the roots to divide more rapidly, having an impressive impact on eyelash growth in particular.  Biotin tripeptide-1 stimulates the production of adhesion molecules collagen IV and laminin 5 in dermal and epidermal cells (which helps with hair anchorage).

The manufacturer did some in-vitro studies that show the molecule can localize to human hair follicles, inducing keratinocyte proliferation, increasing hair growth by 58% and 121% compared with control follicles when used at concentrations of 2 and 5 ppm, respectively.   

Eye lashes appeared over 19% thicker after 30 days of using serum formulations containing Biotinoyl Tripeptide-1.