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Bev Sidders Skincare Glossary

Epidermal Growth Factor (EGF)

Products with EGF (rhEGF) are an important topical therapeutic modality to treat aging skin efficiently and to treat hyper-pigmentation, wrinkles, dryness, and laxity.  The EGF is effective in the advanced healing of skin wounds, according to the results of multiple investigations in severe cases, although studies are required to establish concentrations and indications of use for each case.
From fibroblast cell cultures with EGF, it was determined that EGF promotes the migration and contractility of aged fibroblasts and increases the production of hyaluronic acid and the synthesis of collagen.  Hence, it possesses potential as a regenerator of skin aging.

Peptides with EGF that penetrate the skin when applied topically have been developed; cosmeceuticals with EGF that prevent or improve wrinkles and hydrate the skin without significant side effects are being formulated.

EGF is a noninvasive and effective treatment for melasma.  The EGF acts on the melanocytes by reducing the expression of melanogenesis‐associated proteins (e.g. tyrosinase/MITF microphthalmia-associated transcription factor), in consequence inhibiting or regulating melanin synthesis.  It is also effective in preventing post-inflammatory hyperpigmentation after fractional CO2 laser treatment; its daily application resulted in significant stimulation of healing with slight pruritus.

Topical serum twice a day for 8 weeks decreased melasma in 73.4% cases of the experimental group without any side effects.  Other research confirmed that EGF prevents inflammatory hyper pigmentation by laser treatment at 3, 7, and 35 days after its use. 

EGF contributes to restructuring the skin tissue; it improves facial acne, both inflammatory and noninflammatory, when it is applied as an EGF cream for 6 weeks. It also decreases sebum production and increases hydration, whereby the topical EGF may be an effective and safe adjuvant treatment option for mild to moderate vulgar acne.