sh-Polypeptide-3 is a single-chain synthetic recombinant peptide, an analog of human KGF (Keratinocyte Growth Factor). KGF was first described in 1989 as a human growth factor that stimulated epithelial cell proliferation.
sh-Polypeptide-3 affects the proliferation and differentiation of various cell types as it is a part of the Fibroblast growth factor (FGF) superfamily. KGF is involved in early hair growth as an important go-between.
sh-Polypeptide-3 promotes dermal cell adhesion, spreading, and proliferation and boosts regenerative processes in the skin and wound healing. It is an important mediator in epithelial repairs and mesenchymal interactions.