Glycation

Glycation, a major factor of intrinsic aging, occurs when excess sugar molecules bind to collagen and elastin fibers and prompt the formation of advanced glycation end-products (A.G.E.) that may lead to the appearance of aging.  As a result, glycated collagen and elastin fibers lose the ability to function normally, and the body cannot break them down and replace them, leading to severe wrinkling of the skin.