A-Z — Palmitoyl Oligopeptide

Haloxy l™ is made out of a combination of ingredients, but has four main components. N-hydroxysuccinimide – This ingredient is used to help condition and soften the skin (referred to as an “ester”). It is also considered a reagent, which is a substance that is used to trigger a reaction that results in a new substance (like peptides and polymers).  Palmitoyl Oligopeptide – A peptide that is one of the newer on the market, used for its reported ability to potentially stimulate the production of collagen and promote the healthy functioning of skin cells.  Palmitoyl Tetrapeptide-3 – Not to be confused with Palmitoyl Oligopeptide,...

Palmitoyl Tripeptide-1, also known as palmitoyl oligopeptide (trade-named Matrixyl™ 3000 - yes, these names get confusing!) is a synthetic fatty acid-linked peptide that can help repair visible skin damage and strengthen skin’s underlying supportive elements. It’s categorized as a messenger peptide because of its ability to “tell” skin how to look better, specifically in regard to visibly fading signs of sun damage like wrinkles and rough texture. Can be used with retinol or tretinoin for even greater anti-aging benefits.  

Developed in 1994.  By 2011, "Palmitoyl Oligopeptide" was the most used peptide in cosmetic products.  In 2013, the name was "used to designate two distinct molecules" and those compounds were renamed as: Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Hexapaptide-12 (Pal-KTTKS).   Both act by stimulating fibroblast activity, thus increasing matrix protein and glycosaminoglycan synthesis in the dermis.  In other words, anti-aging peptides clinically proven to reduce wrinkle depth by stimulating the synthesis of collagen, elastin, glucosaminoglycans and hyaluronic acid in the deep layers of the skin.   In 2018, Palmitoyl Tripeptide-1 (Pal-GHK) was the second most used peptide in cosmetic formulations.  Matrixyl™ 3000 is the commercial name...