A-Z — Palmitoyl Tripeptide-1

Biotin tripeptide-1 is an extracellular matrix (ECM) cell-communicating peptide (Palmitoyl Tripeptide-1) that has been conjugated to biotin.  It has been found helpful for reducing hair loss, increasing hair growth and making eye lashes appear longer, fuller and stronger.   Biotinoyl tripeptide-1 increases the population of anagen hair, which is the active growth phase of hair follicles. It provokes the cells in the roots to divide more rapidly, having an impressive impact on eyelash growth in particular.  Biotin tripeptide-1 stimulates the production of adhesion molecules collagen IV and laminin 5 in dermal and epidermal cells (which helps with hair anchorage). The...

Palmitoyl Tripeptide-1, also known as palmitoyl oligopeptide (trade-named Matrixyl™ 3000 - yes, these names get confusing!) is a synthetic fatty acid-linked peptide that can help repair visible skin damage and strengthen skin’s underlying supportive elements. It’s categorized as a messenger peptide because of its ability to “tell” skin how to look better, specifically in regard to visibly fading signs of sun damage like wrinkles and rough texture. Can be used with retinol or tretinoin for even greater anti-aging benefits.  

Developed in 1994.  By 2011, "Palmitoyl Oligopeptide" was the most used peptide in cosmetic products.  In 2013, the name was "used to designate two distinct molecules" and those compounds were renamed as: Palmitoyl Tripeptide-1 (Pal-GHK) and Palmitoyl Hexapaptide-12 (Pal-KTTKS).   Both act by stimulating fibroblast activity, thus increasing matrix protein and glycosaminoglycan synthesis in the dermis.  In other words, anti-aging peptides clinically proven to reduce wrinkle depth by stimulating the synthesis of collagen, elastin, glucosaminoglycans and hyaluronic acid in the deep layers of the skin.   In 2018, Palmitoyl Tripeptide-1 (Pal-GHK) was the second most used peptide in cosmetic formulations.  Matrixyl™ 3000 is the commercial name...